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Brian
Clark
University of aarhus
Institute of molecular biology
Danish Centre for Molecular Gerontology
Aarhus, Denmark |
Research
interests and relevant experience of responsible scientist
Brian
F. C. Clark has been Professor of Biostructural Chemistry at the
University of Aarhus in Denmark since 1974. At present, he is
also the Leader of the Danish Centre for Molecular Gerontology
at the Institute of Molecular Biology.
He was on the scientific staff of the British Medical Research
Council Laboratory of Molecular Biology from 1964-74 working in
the Division of Molecular Genetics co headed by Francis Crick
and Sydney Brenner. His current research interests involve the
relation structure and function of macromolecules and the identification
of functional proteins in functional genomics.
He also works on protein engineering and molecular gerontology.
His scientific contribution comprises more than 200 articles.
He was recently Vice-Chairman of the European Molecular Biology
Organization Council (EMBO) and President of the International
Union of Biochemistry and Molecular Biology (IUBMB).
He is presently Chairman of TGIR (Task Group on International
Relations) of the European Federation of Biotechnology (EFB) and
Co-Chairman of EFBIC (European Focus on Biotechnology in China).
His expertise in Technology transfer is provided by his being
on the board of BankInvest, a leading European Venture Capital
Fund focussing on Biotechnology. Brian F. C. Clark is currently
the coordinator of the European Integrated Project PROTEOMAGE.
Staff
Brian
F. C. Clark, Professor
Peter Kristensen, Associate Professor
Suresh I.S. Rattan, Professor
Yvonne Eskildsen-Helmond, Assistant Professor
Regina Gonzalez-Dosal, Research Assistant
Gunhild Siboska, Senior Technician
Helle Jakobsen, Technician
Relevant
publications
Gonzalez-Dosal
R, Sorensen MD, Clark BF, Rattan SI & Kristensen P. Phage-displayed
antibodies for the detection of glycated proteasome in aging cells.
Ann N Y Acad Sci 2006; 1067:474-8.
Rattan
SI & Clark BF. Understanding and modulating ageing. IUBMB
Life 2005; 57:297-304.
Beedholm
R, Clark BF & Rattan SI. Mild heat stress stimulates 20S proteasome
and its 11S activator in human fibroblasts undergoing aging in
vitro. Cell Stress Chaperones 2004; 9:49-57.
Jensen
KB, Jensen ON, Ravn P, Clark BF & Kristensen P. Identification
of Keratinocyte-specific Markers Using Phage Display and Mass
Spectrometry. Mol Cell Proteomics 2003; 2:61-9.
Fonager
J, Beedholm R, Clark BF & Rattan SI. Mild stress-induced stimulation
of heat-shock protein synthesis and improved functional ability
of human fibroblasts undergoing aging in vitro. Exp Gerontol 2002;
37:1223-8.
Verbeke
P, Clark BFC & Rattan SIS. Reduced levels of oxidized and
glycoxidized proteins in human fibroblasts exposed to repeated
mild heat shock during serial passaging in vitro. Free Radical
Biology and Medicine 2001; 31:1593-602.
Nordhoff
E, Korgsdam AM, Jørgensen HF, Kallipolitis BH, Clark BFC,
Roepstorff P & Kristiansen K. Rapid identification of DNA-binding
proteins by mass spectrometry. Nature Biotech 1999; 17:884-8.
Nissen
P, Kjeldgaard M, Thirup S, Polekhina G, Reshetnikova L, Clark
BFC & Nyborg J. Crystal structure of the ternary complex of
Phe-tRNAPhe, EF-Tu, and a GTP analog. Science 1995; 270:1464-72
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