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Efstathios S. Gonos
National Hellenic Research Foundation (NHRF)
Institute of biological research and biotechnology
Programme of Molecular & Cellular Ageing
Athens, Greece |
Research
interests and relevant experience of responsible scientist
Efstathios
Gonos is doing research on biological ageing since 15 years. He
is the leader of the Molecular and Cellular Ageing Programme at
the National Hellenic Research Foundation. Research of the lab
concerns genetic and environmental factors linked to human ageing
and longevity.
Functional
genomics approaches have been used to identify genes implicated
in cell survival and associated with the appearance of age-related
diseases, such as diabetes type II or coronary heart disease.
Emphasis is also given to molecular understanding of the impaired
function of the proteasome during ageing. The Programme holds
a collection of samples (PBMC, skin fibroblasts) of donors of
different ages, including healthy centenarians, to study agents
that affect the cellular ageing process, as well as to identify
gene variants that are linked with longevity. Efstathios Gonos
is member of the following E.U. projects (FP-5 and FP-6) on ageing:
GENAGE, PROTAGE, CELLAGE, FUNCTIONAGE, GEHA and ZINCAGE.
He
was the chairman of the 2nd Euroconference on “Biological
Ageing” and he is a senior expert of the European Union/FP-6
in the thematic area: “Study human development and the ageing
process”. Efstathios Gonos is an Editorial Board member
of: “Aging Cell”, “Biogerontology”, “Experimental
Gerontology” and “Mechanisms of Ageing and Development”.
Staff
Efstathios
S. Gonos, Res. Professor, Director of Research
Ioannis P. Trougakos, Research Lecturer, molecular survival factors
Niki Chondrogianni, Research Fellow, protein degradation
Christos Tzavellas, Research Fellow, protein degradation
Ioannis Nezis, Research Fellow, replicative senescence
Triantafillia Ntouroupi, Research Fellow, molecular survival factors
Magda Katsiki, Ph.D. Student, anti-ageing drugs screening
Magda Lourda, Ph.D. Student, molecular survival factors
Efthimios Poulios, Ph.D. Student, replicative senescence
Ioanna Ioannou, Research Officer, databases
Relevant
publications
Poulios
E, Trougakos IP & Gonos ES. Comparative effects of hypoxia
on normal and immortalized human diploid fibroblasts. Anticancer
Res 2006; 26:2165-8.
Trougakos IP, Petropoulou C, Franceschi C &
Gonos ES. Reduced expression levels of the senescence biomarker
clusterin/apolipoprotein j in lymphocytes from healthy centenarians.
Ann N Y Acad Sci 2006; 1067:294-300.
Chondrogianni N & Gonos ES. Proteasome dysfunction
in mammalian aging: steps and factors involved. Exp Gerontol 2005;
40:931-8.
Chondrogianni N, Tzavelas C, Pemberton AJ, Nezis
IP, Rivett AJ & Gonos ES. Overexpression of proteasome beta5
assembled subunit increases the amount of proteasome and confers
ameliorated response to oxidative stress and higher survival rates.
J Biol Chem 2005; 280:11840-50.
Chondrogianni N, de C M Simoes D, Franceschi C
& Gonos ES. Cloning of differentially expressed genes in skin
fibroblasts from centenarians. Biogerontology 2004; 5:401-9.
Chondrogianni N, Stratford FLL, Trougakos IP,
Friguet B, Rivett AJ & Gonos ES. () Central role of the proteasome
in senescence and survival of human fibroblasts: induction of
a senescence-like phenotype upon its inhibition and resistance
to stress upon its activation. J Biol Chem 2003; 278:28026-37.
Barradas M, Gonos ES, Zebedee Z, Kolettas E, Petropoulou
C, Dolores-Delgado M, Leon J, Hara E & Serrano M. Identification
of a candidate tumor suppressor gene specifically activated during
ras-induced senescence. Exp Cell Res 2002; 273:127-37.
Mondello C, Petropoulou C, Monti D, Gonos ES,
Franceschi C & Nuzzo F. Telomere length in fibroblasts and
blood cells from healthy centenarians. Exp Cell Res 1999; 248:234-42.
Gonos ES, Derventzi A, Kveiborg M, Agiostratidou
G, Kassem M, Clark BFC, Jat PS & Rattan SIS. Cloning and identification
of genes that associate with mammalian replicative senescence.
Exp Cell Res 1998; 240:66-74.
Gonos
ES, Burns JS, Mazars GR, Kobrna A, Riley TEW, Barnet SC, Zafarana
G, Ludwig R, Ikram Z, Powell AJ & Jat PS. Rat embryo fibroblasts
immortalized with SV40 large T antigen undergo senescence upon
its inactivation. Mol Cell Biol 1996; 16:5127-5138.
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