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Gillian Butler-Browne
University of Pierre and Marie Curie
Faculty of Medicine, Pitié-Salpêtrière
UMR CNRS 7000 - cytoskeleton and development group
Paris, France |
Research
interests and relevant experience of responsible scientist
Gillian
Butler-Browne is the leader of a research group on human muscle
ageing and pathologies associated to the muscle. She has been
established in Paris VI since 1998 in Pitié-Salpétrière
Hospital, which is renowned internationally for neurology and
neuromuscular research. Gillian Butler-Browne is a member of the
AFM scientific board (Association Française de Lutte Contre
les Myopathies).
She
has collaborated through FP5 with Pr Saillant in the Orthopaedic
department, world-renowned in sports medicine, and others. She
has worked on the regenerative capacity of human skeletal muscle
with age and in various physiological conditions, including athletes,
as well as in neuromuscular diseases.
Staff
Gillian
Butler-Browne, DR1 INSERM, Lab leader, ageing, regeneration
Vincent Mouly, CR1 CNRS, Group leader
Philippe Noirez, MCU Paris 5, Myosin isoforms
Denis Furling, Post-doc, Muscle diseases in vitro and gene therapy
Valérie Renault, PhD student, Muscle ageing, oxidative
stress
Virginie Jacquemin, PhD student, Mechanism of hypertrophy
Anne Bigot, PhD student, Control of cell cycle
Elisa Negroni, PhD student, Ex vivo regenerative capacity
To Be Recruited, Post-doc, Ex vivo model for diseasessatellite
cells in vivo
Gérard Saillant, PU/PH, Dean and Head of the Orthopaedic
Dept (collaborator)
Lars-Eric Thornell, Prof, Head of Anatomy Dept, Umea, Sweden (collaborator)
Relevant
publications
Mouly V, Aamiri A, Perie S, Mamchaoui
K, Barani A, Bigot A, Bouazza B, Francois V, Furling D, Jacquemin
V, Negroni E, Riederer I, Vignaud A, St Guily JL & Butler-Browne
GS. Myoblast transfer therapy: is there any light at the end of
the tunnel? Acta Myol 2005; 24:128-33.
Jacquemin V, Furling D, Bigot A, Butler-Browne
GS & Mouly V. IGF-1 induces human myotube hypertrophy by increasing
cell recruitment. Exp Cell Res 2004; 299:148-58.
Agbulut O, Noirez P, Beaumont F & Butler-Browne
G. Myosin heavy chain isoforms in postnatal muscle development
of mice. Biol Cell 2003; 95:399-406.
Cooper RN, Thiesson D, Furling D, DiSanto JP,
Butler-Browne GS & Mouly V. Extended amplification in vitro
and replicative senescence: key factors implicated in the success
of human myoblast transplantation. Hum Gene Ther 2003; 14:1169-79.
Renault V, Thornell LE, Ericksson PO, Butler-Browne
GS & Mouly V. Regenerative potential of human skeletal muscle
during ageing. Aging Cell 2002; 1:132-39.
Furling D, Coiffier L, Mouly V, Lacau St Guily
J, Taneja K, Gourdon G, Junien C & Butler-Browne GS. Defective
satellite cells in congenital myotonic dystrophy. Hum Mol Genet
2001; 10:2079-87.
Cooper R, Irintchev A, Di Santo JP, Zweyer M,
Morgan JE, Partridge TA, Butler-Browne GS, Mouly V & Wernig
A. A new immunodeficient mouse model for human myoblast transplantation.
Hum Gen Ther 2001; 12:823-31.
Renault V, Piron-Hamelin G, Forestier C, DiDonna
S, Decary S, Hentati F, Saillant G, Butler-Browne GS & Mouly
V. Skeletal muscle regeneration and the mitotic clock. Expt Geron
2000; 35:711-19.
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