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Heinz D. Osiewacz
Johann Wolfgang Goethe-University
Institute of Molecular Biosciences
Molecular Developmental Biology group
Frankfurt, Germany |
Research
interests and relevant experience of responsible scientist
Heinz
Osiewacz is leading the group on Molecular Developmental Biology
& Biotechnology. He has a long-standing experience in the
field of experimental gerontology. Research is devoted to unravel
the molecular network of pathways controlling ageing in the fungal
model Podospora anserina.
In
particular, mitochondrial/nuclear interactions (cross talk), mitochondrial
DNA instabilities, respiration, retrograde signalling, ROS generation
and scavenging are investigated at the genetic, biochemical, cytological,
and physiological level. A central issue of the research is the
analysis of long-lived mutants and of specific transgenic strains
to raise functional and mechanistic data. All equipment to perform
the research in the field of experimental ageing research with
P. anserina is available in the group. For his work on
molecular mechanisms of ageing Heinz Osiewacz received in 1985
the Sandoz Prize of Gerontology by the International Association
of Gerontology and in 2001 the Rene-Schubert Prize for Gerontology
by the German Society of Gerontology.
He
edited (co-edited) three books on Gerontology with two recent
books on “Model organisms”. Heinz Osiewacz is in the
editorial board of Experimental Gerontology, Biogerontology, and
Current Genetics. He was co-organizer of the European Molecular
Biology Organisation Workshop on Molecular Gerontology in 1999.
Heinz D. Osiewacz has been partner in two EU concerted action
programmes and is currently coordinator of the Integrated Project
Mimage and participant to PROTEOMAGE and LINK-AGE.
Staff
Heinz
D. Osiewacz, Prof. Dr., Senior Scientist (JWGU)
Dr. Markus Bucher, Project Manager
Dr. Andrea Hamann
Dr. Christian Scheckhuber
Yasmine Bernhards, PhD student
Diana Brust, PhD student
Jürgen Grief, PhD student
Karin Jezek, PhD student
Birgit Kunstmann, PhD student
Alexandra Werner, Technician
Gabriele Seelbach, Technician
Sieglinde Kost, Technician
Barbara Tarazi, Secretary
A variable number of diploma thesis students
Relevant
publications
Scheckhuber
C & Osiewacz HD. The role of mitochondria in conserved mechanisms
of aging. Sci Aging Knowledge Environ 2006; 2006:pe15.
Gredilla
R, Grief J & Osiewacz HD. Mitochondrial free radical generation
and lifespan control in the fungal aging model Podospora anserina.
Exp Gerontol 2006; 41:439-47.
Scheckhuber
C & Osiewacz HD. MiMage: a Pan-European project on the role
of mitochondria in aging. Sci Aging Knowledge Environ 2005; 2005:pe14.
Krause
F, Scheckhuber CQ, Werner A, Rexroth S, Dencher NA & Osiewacz
HD. Supramolecular organization of COX- and AOX-dependent respiratory
chains in the filamentous fungus Podospora anserina. J Biol Chem
2004; 279:26453-61.
Stumpferl
SW, Stefan O & Osiewacz HD. Impact of a disruption of a pathway
delivering copper to mitochondria on Podospora anserina metabolism
and life span. Eukaryotic Cell 2004; 3:200-11.
Jansen-Durr
P & Osiewacz HD. Healthy ageing: a question of stress, damage
and repair. Meeting on mechanisms of biological ageing. EMBO Rep
2002; 3:1127-32.
Borghouts
C, Werner A & Osiewacz HD. Respiration, copper availability,
and SOD activity in Podospora anserina strains with different
life span. Biogerontology 2002; 3:143-53.
Osiewacz
HD. Genes, mitochondria and aging in filamentous fungi. Ageing
Res Rev 2002; 1:425-42.
Osiewacz
HD. Mitochondrial functions and aging. Gene 2002; 286:65-71.
Osiewacz
HD. Aging in fungi: role of mitochondria in Podospora anserina.
Mech Ageing Dev 2002; 123:755-64.
Borghouts
C, Werner A, Elthon T & Osiewacz HD. Copper-modulated gene
expression and senescence in the filamentous fungus Podospora
anserine. Mol Cell Biol 2001; 21:390-9.
Borghouts
C, Kimpel E & Osiewacz HD. Mitochondrial DNA rearrangements
of Podospora anserina are under the control of the nuclear gene
grisea. Proc Natl Acad Sci USA 1997; 94:10768-73.
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