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Jacques Vanfleteren
Ghent University
Department of Biology
Aging physiology, cellular physiology and molecular evolution
Ghent, Belgium |
Research
interests and relevant experience of responsible scientist
Major
research topics of Jacques Vanfleteren’s team include the
role of protein turnover (synthesis and degradation) in the ageing
process in C. elegans, the study of the genes that are
up/down regulated in axenic culture relative to culture on E.
coli, the study of the effects of ROS and anti-oxidant defence
on life expectancy in C. elegans, using pharmacological
and genetic interventions, the study of the role of the mitochondrial
function as a modulator of life span determination in C. elegans,
the metabolic alterations in long lived mutants of C. elegans,
D. melanogaster (collaboration with L. Partridge and
D. Gems) and P. anserina (collaboration with H. Osiewacz).
Jacques
Vanfleteren coordinated the Shared-Cost RTD action AGEGEN (2000-2003)
and is a participant of the current Integrated Project MIMAGE
and the Coordination Action LINK-AGE.
Staff
Jacques Vanfleteren, Head of the
research section Physiology of Ageing and Molecular Evolution
Bart Braeckman, Associate Professor in Biology
Koen Houthoofd, Post-doc research scientist with the Fund for
Scientific Research-Flanders
Isabelle Lenaerts, PhD student
Kristel Brys, PhD student
Filip Matthijssens, PhD student
David Hoogewijs, PhD student
Annemie De Vreese, technician
Andy Vierstaete, technician
Sylvie Van Eygen, technician
Relevant
publications
Braeckman
BP & Vanfleteren JR. Genetic control of longevity in C.
elegans. Exp Gerontol 2006; [Epub ahead of print]
Braeckman
BP, Demetrius L & Vanfleteren JR. The dietary restriction
effect in C. elegans and humans: is the worm a one-millimeter
human? Biogerontology 2006; [Epub ahead of print]
Houthoofd
K, Fidalgo MA, Hoogewijs D, Braeckman BP, Lenaerts I, Brys K,
Matthijssens F, De Vreese A, Van Eygen S, Munoz MJ & Vanfleteren
JR. Metabolism, physiology and stress defense in three aging Ins/IGF-1
mutants of the nematode Caenorhabditis elegans. Aging
Cell 2005; 4:87-95.
Houthoofd
K, Braeckman BP, Johnson TE & Vanfleteren JR. Extending life-span
in C. elegans. Science 2004; 305:1238-9.
Keany
M, Matthijssens F, Sharpe M, Vanfleteren J & Gems D. Superoxide
dismutase mimetics elevate superoxide dismutase activity in vivo
but do not retard aging in the nematode Caenorhabditis elegans.
Free Rad Biol Med 2004; 37:239-50.
Chen C, Dewaele S, Braeckman B, Desmyter L, Verstraelen
J, Borgonie G, Vanfleteren J & Contreras R. A high-throughput
screening system for genes extending life-span. Exp Gerontol 2003;
38:1051-63.
Houthoofd
K, Braeckman BP, Johnson TE & Vanfleteren JR. Life extension
via dietary restriction is independent of the Ins/IGF-1 signalling
pathway in Caenorhabditis elegans. Exp Gerontol 2003;
38:947-54.
Braeckman
BP, Houthoofd K, De Vreese A & Vanfleteren JR. Apparent uncoupling
of energy production and consumption in long-lived Clk mutants
of Caenorhabditis elegans. Curr Biol 1999; 9:493-6.
Vanfleteren
JR & De Vreese A. The gerontogenes age-1 and daf-2 determine
metabolic rate potential in aging Caenorhabditis elegans.
FASEB J 1995; 9:1355-61.
Vanfleteren
JR. Oxidative stress and ageing in Caenorhabditis elegans.
Biochem J 1993; 292:605-8.
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