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Olivier
Toussaint
University of Namur
Research Unit on Cell Biology
Namur, Belgium |
Research
interests and relevant experience of responsible scientist
Dr
Toussaint’s research is focused on cell senescence and the
role of stress, including experimental and theoretical studies.
The group has particular experience in studying induction of biomarkers
of senescence by subcytotoxic stress (e.g. oxidative stress and
UVB), with expertise in proteome & transcriptome analyses
to identify proteins and mRNAs involved in stress-induced premature
senescence (SIPS).
The
group has collaborated with Eppendorf Array Technologies to develop
a low density DNA array allowing studies of cellular senescence
and SIPS. Dr Toussaint is or has been Coordinator or Member of
6 EU-funded projects: Protage (FP5), Functionnage (CO, FP5), Geha
(FP6, Proteomage (FP6), Link-age (CO, FP6).
Dr
Toussaint has experience in organizing Major International Scientific
Conferences, including a Euroconference on Biological Ageing in
2000 and a European Molecular Biology Organisation Workshop on
Molecular Gerontology in 1999.
Staff
Olivier Toussaint, PhD, Senior Scientist
(FNRS), LINK-AGE coordinator
Béatrice Rayet, PhD, LINK-AGE deputy coordinator
Florence Chainiaux, PhD
Thierry Pascal, PhD Student
Stéphanie Zdanov, PhD Student
Céline Borlon, PhD Student
Aline Chrétien, Ph D Student
Valérie Deglas,
Véronique Flament, PhD Student
Jérôme Marijsse, PhD student
Véronique Vallery, PhD Student
Geoffroy Weemaels, PhD Student
Coralie Bastin, Technician
Anne Deneffe, Part-time secretary
Relevant
publications
Zdanov S, Remacle J & Toussaint
O. Establishment of H2O2-induced premature senescence in human
fibroblasts concomitant with increased cellular production of
H2O2. Ann N Y Acad Sci 2006; 1067:210-6.
Pascal T, Debacq-Chainiaux F, Chretien A, Bastin
C, Dabee AF, Bertholet V, Remacle J, Toussaint O. Comparison of
replicative senescence and stress-induced premature senescence
combining differential display and low-density DNA arrays.
FEBS Lett 2005; 579:3651-9.
Matthews E, Haimes E, Duguet AM, Clark BF, Swine
C, Toussaint O. Informed consent of very old patients and modern
genomics. Biogerontology 2005; 6:81-4.
Debacq-Chainiaux F, Borlon C, Pascal T, Royer
V, Carrard G, de Longueville F, Boffe A, Eliaers F, Friguet B,
Remacle J & Toussaint O. Repeated exposures of human skin
fibroblasts to UVB at subcytotoxic level trigger premature senescence
through the TGF-ß1 signaling pathway. J Cell Sci 2005; 118:743-58
de Magalhães JP, Costa J & Toussaint
O. HAGR : The Human Ageing Genomic Resources. Nucl Acid Res 2005;
33:D537-43
Pascal, T., Debacq-Chainiaux, F., Chrétien,
A., Bastin, C., Dabée, A.-F., Bertholet, V., Remacle, J.
& Toussaint, O. Comparison of replicative senescence and stress-induced
premature senescence combining differential display and low-density
DNA arrays. FEBS Lett 2005; 579:3651-3659
de Magalhaes JP, Chainiaux F, Remacle J, Toussaint
O. Stress-induced premature senescence in BJ and hTERT-BJ1 human
foreskin fibroblasts. FEBS Lett 2002; 523:157-62
Frippiat
C, Chen QM, Zdanov S, Magalhaes JP, Remacle J & Toussaint
O. Subcytotoxic H2O2 stress triggers a release of Transforming
Growth Factor-ß1, which induces stress-induced premature
senescence of human diploid fibroblasts. J Biol Chem 2001; 276:2531-7
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