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Eline P. Slagboom
Leiden University Medical Centre
Research Molecular Epidemiology
Leiden, The Netherlands |
Research
interests and relevant experience of responsible scientist
With
15 years of experience in ageing research, following training
in biology and genetics, Eline Slagboom has established research
lines into genetics of complex traits and diseases with special
focus on osteoarthritis (OA), lipid research and ageing. To achieve
this aim Slagboom’s group has set up various epidemiological
studies that allow for both genetic linkage and association studies
(cohort and sib pair studies for OA and longevity).
Since
three years ago, Eline Slagboom has been full professor of molecular
epidemiology at LUMC. She has established a high throughput genotyping
platform that is involved in genotyping in genetic epidemiological
studies of LUMC, and the Universities of Amsterdam and Rotterdam.
Eline
Slagboom has a strong experience as conference organizer (including
a major international conference on molecular biology of ageing,
organised under the auspices of the EURAGE Concerted Action).
She has been member of two previous FP5 EU projects, Protage and
Functionnage. From her previous work at the Dutch commercially
oriented research organization TNO she has strong experience of
links with industry.
Staff
PE Slagboom, Professor of Molecular
Epidemiology, Head of Department of Molecular Epidemiology
BT Heijmans, PhD Research fellow, QTL mapping
I Meulenbelt, PhD Lecturer, Genetics of osteoarthritis
B Brandt, PhD Research fellow, Bioinformatics
M Beekman, PhD, Human longevity
RGJ Westendorp, Professor of Gerontology
D van Heemst PhD, Longevity, genomics
Bas Zwaan, Lecturer, Evolutionary biology
Relevant
publications
Kuningas M, Mooijaart SP, Slagboom
PE, Westendorp RG & van Heemst D. Genetic variants in the
glucocorticoid receptor gene (NR3C1) and cardiovascular disease
risk. The Leiden 85-plus Study. Biogerontology 2006 May 5; [Epub
ahead of print]
Beekman M, Blauw GJ, Houwing-Duistermaat JJ, Brandt
BW, Westendorp RG & Slagboom PE. Chromosome 4q25, microsomal
transfer protein gene, and human longevity: novel data and a meta-analysis
of association studies. J Gerontol A Biol Sci Med Sci 2006; 61:355-62.
Schoenmaker M, de Craen AJ, de Meijer PH, Beekman
M, Blauw GJ, Slagboom PE & Westendorp RG. Evidence of genetic
enrichment for exceptional survival using a family approach: the
Leiden Longevity Study. Eur J Hum Genet 2006; 14:79-84.
Heijmans BT, Beekman M, Putter H, Lakenberg N,
van der Wijk HJ, Whitfield JB, Posthuma D, Pedersen NL, Martin
NG, Boomsma DI & Slagboom PE. Meta-analysis of four new genome
scans for lipid parameters and analysis of positional candidates
in positive linkage regions. Eur J Hum Genet 2005; 13:1143-53.
van Heemst D, Beekman M, Mooijaart SP, Heijmans
BT, Brandt BW, Zwaan BJ, Slagboom PE & Westendorp RG. Reduced
insulin/IGF-1 signalling and human longevity. Aging Cell 2005;
4:79-85.
Brandt BW, Zwaan BJ, Beekman M, Westendorp RG
& Slagboom PE. Shuttling between species for pathways of lifespan
regulation: a central role for the vitellogenin gene family? Bioessays
2005; 27:339-46.
Beekman M, Heijmans BT, Martin NG, Whitfield JB,
Pedersen NL, DeFaire U, Snieder H, Lakenberg N, Suchiman HED,
Knijff P de, Frants RR, Ommen GJB van, Kluft C, Vogler GP, Boomsma
DI & Slagboom PE. Evidence for a QTL on chromosome 19 influencing
LDL cholesterol levels in the general population. Eur J Hum Genet
2003; 11:845-50.
Meulenbelt I, Seymour AM, Nieuwland M, Huizinga
TWJ, Duijn CM van & Slagboom PE. Association of the Interleuking-1
gene cluster with radiographic signs of osteoarthritis in the
hip. Arthritis & Rheumatism 2004; 50:1179-86.
Heijmans BT, Boer JMA, Suchiman HED, Cornelisse
CJ, Westendorp RGJ, Kromhout D, Feskens EJM & Slagboom PE.
A common variant of the methylenetetrahydrofolate reductase gene
(1p36) is associated with an increased risk of cancer. Cancer
Res 2003; 63:1249-53.
Heijmans BT, Westendorp RGJ & Slagboom PE.
Common gene variants, mortality and extreme longevity in humans.
Exp Gerontol 2000; 35:865-77.
Slagboom
PE, Droog S & Boomsma DI Genetic determination of telomere
size in humans: a twin study of three age groups. Am J Hum Genet
1994; 55:876-82.
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