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Thomas
Nyström
Göteborg University
Department of Cell and Molecular Biology
Bacterial ageing and stasis survival
Göteborg, Sweden |
Research
interests and relevant experience of responsible scientist
The
subject matter of Thomas Nystrom team research in cellular senescence
include the defence against oxidative damage to proteins, the
global regulatory circuits activated to defend against macromolecular
deterioration and protein aberrancies, the links between translational
fidelity and oxidation of aberrant proteins.
Their
aim is to achieve an integrated understanding of the molecular
mechanisms underlying damage defence, damage segregation/cellular
rejuvenation and to elucidate how failures in damage control lead
to perturbed homeostasis and aging. Thomas Nystrom is now head
for the Institute of cell and molecular biology.
He
is a member of EMBO and the Royal Academy of Sciences and an honorary
fellow of the American Academy of Microbiology. He was awarded
the Goran Gustafsson Award in Molecular Biology 2002 by the Royal
Academy, the most prestigious Science award at the national level
in Sweden, for his research on microbial aging models.
Staff
Thomas Nyström, Senior scientist,
Head of Microbiology, Head of Cell and Molecular Biology
Anne Farwell, Research Assistant, Lecturer
Lisa Magnusson, Research Assistant
Laurence Nachin, Post doc.
Lydie Hlavata, Post doc
Malin Hernebring, PhD student
Rebecka Hansson, Lic Student
Asa Fredriksson, PhD Student,
Orjan Persson, PhD student
Bertl Gummesson, PhD student
Nika Erjavec, PhD student
Elin Johansson, PhD Student
Relevant
publications
Hernebring M, Brolen G, Aguilaniu
H, Semb H & Nystrom T. Elimination of damaged proteins during
differentiation of embryonic stem cells. Proc Natl Acad Sci U
S A 2006; 103:7700-5.
Nystrom T. Role of oxidative carbonylation in
protein quality control and senescence. EMBO J 2005; 24:1311-7.
Nystrom T. The free-radical hypothesis of aging
goes prokaryotic. Cell Mol Life Sci 2003; 60:1333-41.
Nystrom T. Conditional senescence in bacteria:
death of the immortals. Mol Microbiol 2003; 48:17-23.
Aguilaniu H, Gustafsson L, Rigoulet M & Nyström,
T. Asymmetric inheritance of oxidatively damaged proteins during
cytokinesis. Science 2003; 299:1751-53.
Hlavata L, Aguilaniu H, Pichova A & Nyström
T. The oncogenic Ras2val19 allele elevates ROS production and
locks mitochondrial respiration in a non-phosphorylating mode
independently of the PKA pathway. EMBO J 2003; 22:3337-45.
Jishage M, Kvint K, Shingler V & Nyström,
T. Regulation of sigma factor competition by the alarmone ppGpp.
Genes Dev 2002; 16:1260-70.
Dukan S, Farewell A, Ballestreros M, Taddei F,
Radman M & Nyström, T. Proteins are oxidatively carbonylated
in response to reduced transcriptional or translational fidelity.
Proc Natl Acad Sci USA 2000; 97:5746-9.
Dukan S & Nyström T. Stasis results in
increased and differential oxidation of cytoplasmic proteins leading
to developmental induction of the heat shock regulon. Genes Dev
1998; 12:3431-41.
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