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Prof.
Dr. Christos C. Zouboulis
Dessau Medical Center
Dessau, Germany
Departments of Dermatology and Immunology
Charité Universitaetsmedizin
Institute of Clinical Pharmacology and Toxicology
Laboratory for Biogerontology, Dermato-Pharmacology and Dermato-Endocrinology
Berlin, Germany |
Research
interests and relevant experience of responsible scientist
The
group of Prof. Christos Zouboulis uses skin cell cultures and
3D-skin equivalent models to investigate the molecular skin ageing
mechanisms. Moreover, the group investigates endocrine regulation
as fundamental mechanism of intrinsic skin ageing and tests antisense
oligonucleotides and siRNA molecules against genes associated
with skin ageing.
Among other prizes, Christos Zouboulis has been awarded the “Felix
Wankel Animal Protection Research Award 2000” for developing
skin models to substitute animals in studying human diseases,
the “Oskar Gans Major Prize” for Dermatological Research
in 1993, the “European Academy of Dermatology and Venereology
Dermatology Research Fellowship” in 1997, the “Beauty
Care Prize” for excellence in Dermatological Cosmetological
Research in 2000 and 2002 and the “Paul Gerson Unna Research
Award” for studies on the innate immunity in 2005.
Christos Zouboulis has experience in organizing major international
and national scientific conferences. He obtains four patents,
the “Sebocytes, sebocyte cell lines and applications thereof,
PCT/EP99/0998”, the “Acne treatment with lipooxigenase
inhibitors, PCT/EP02/04715”, the “Use of microbiology
non-viral substances for treating acne, PCT/EP02/09452”
and the “Use of enzyme inhibitors with aminopeptidase N
and/or dipeptidylpeptidase IV activities and pharmaceutical preparations
produced therefrom for the therapy and prevention of dermatological
diseases with seborrhoeic hyperproliferation and altered differentiation
stages, PCT/EP03/02356”.
Staff
Zouboulis
Christos C., Prof. Dr. med., Professor of Dermatology, Chairman
of the Departments of Dermatology and Immunology, Dessau Medical
Center and Head of the Laboratory for Biogerontology, Dermato-Pharmacology
and Dermato-Endocrinology, Charité Berlin
Trebing Dietrich, Dr. med., Vice-Chair of the Departments of Dermatology
and Immunology, Dessau Medical Center - Dermatological cosmetology
Kroening Yvonne, Dr. med., Faculty member, Departments of Dermatology
and Immunology, Dessau Medical Center – Dermato-surgery,
Dermato-oncology
Brunner Martina, Dr. med., Faculty member, Departments of Dermatology
and Immunology, Dessau Medical Center – Dermato-histology
Fimmel Sabine, Dr. rer. nat., Director of research laboratories
- Molecular therapeutics: antisense oligonucleotides, siRNA
Lakotta Werner, Dipl. chem., Director of clinical laboratories
– Immunology, allergology
Seele Peggy, Dr. med., Dermatology specialist – Cryosurgery,
mycology
Hochheim Dorothee, Dr. med. – Clinical studies: Skin infections
Evgenia Makrantonaki, Dr. med. - Aging research: in vitro models
of intrinsic aging, hormones and aging
Baerenwald Gabryele, Dr. rer. nat. - Clinical laboratories: Mycology
Altenburg Andreas, Dipl. med. - Clinical Studies: Adamantiades-Behçet’s
disease
Theodoridis Athanassios, Dipl. med. - Clinical Studies: malignant
atrophic papulosis
Tsatsou Fragkiski, Dipl. med. – Clinical Studies
Seltmann Holger, Dipl. biol. - Cell Biology: single cell cultures,
combined cell culture models, 3-dimensional skin models
Hermes Bjoern, Dipl. biotechnol., doctorate
Papoutsis Nestor, Dipl. med., doctorate
Angres Sylvia, doctorate
Devermann Lena, diplomate
Assmann Sibylle, technician – Histology
Herrmann Anke, technician - Molecular biology
Kehling Sabine, technician – Clinical laboratories
Zabel Sabine, technician - Clinical laboratories
Relevant
publications
Alestas T, Ganceviciene R, Fimmel
S, Müller-Decker K & Zouboulis CC. Enzymes involved in
the biosynthesis of leukotriene B4 and prostaglandin E2 are active
in sebaceous glands. J Mol Med 2006; 84:75-87
Kosaka S, Kawana S, Zouboulis CC, Hasan T &
Ortel B. Targeting of sebocytes by aminolevulinic acid-dependent
photosensitization. Photochem Photobiol 2006; 82:453-7.
Makrantonaki E, Adjaye J, Herwig R, Brink TC,
Groth D, Hultschig C, Lehrach H & Zouboulis CC. Age-specific
hormonal decline is accompanied by transcriptional changes in
human sebocytes in vitro. Aging Cell 2006; 5:331-44.
Nagy I, Pivarcsi A, Kis K, Koreck A, Bodai L,
McDowell A, Seltmann H, Patrick S, Zouboulis CC & Kemény
L. Propionibacterium acnes and lipopolysaccharide induce the expression
of antibacterial peptides and proinflammatory cytokines/chemokines
in human sebocytes. Microbes Infect 2006; [Epub]
Selleri S, Seltmann H, Gariboldi S, Shirai YF,
Balsari A, Zouboulis CC & Rumio C. Doxorubicin-induced alopecia
is associated with sebaceous gland differentiation. J Invest Dermatol
2006; 126:711-20..
Takeda H, Lyle S, Lazar AJF, Zouboulis CC, Smyth
I & Watt FM. Human sebaceous tumours harbour inactivating
mutations in LEF1. Nat Med 2006; 12:395-7.
Zhang Q, Seltmann H, Zouboulis CC, Konger RL.
Involvement of PPAR-gamma in oxidative stress-mediated prostaglandin
E2 production in SZ95 human sebaceous gland cells. J Invest Dermatol
2006; 126:42-8.
Zhang Q, Seltmann H, Zouboulis CC, Travers JB.
Activation of platelet-activating factor receptor in SZ95 sebocytes
results in inflammatory cytokine and prostaglandin E2 production.
Exp Dermatol 2006; [Epub]
Fimmel S & Zouboulis CC. Influence of physiological
androgen levels on wound healing and immune status in men. Aging
Male 2005; 8:166-74.
Georgel P, Crozat K, Lauth X, Makrantonaki E,
Seltmann H, Sovath S, Hoebe K, Du X, Rutschmann S, Jiang Z, Bigby
T, Nizet V, Zouboulis CC & Beutler B. A toll-like receptor
2-responsive lipid effector pathway protects mammals against skin
infections with gram-positive bacteria. Infect Immun 2005; 73:4512-21.
Sator PG, Schmidt JB, Rabe T & Zouboulis CC.
Skin aging and sex hormones in women -- clinical perspectives
for intervention by hormone replacement therapy. Exp Dermatol
2004; 13:36-40.
Zouboulis CC & Degitz K. Androgen action on
human skin – From basic research to clinical significance.
Exp Dermatol 2004; 13(suppl 4):5-10.
Zouboulis CC. The human skin as a hormone target
and an endocrine gland. Hormones 2004; 3:9-26.
Chen W, Yang CC, Sheu HM, Seltmann H & Zouboulis
CC. Expression of peroxisome proliferator-activated receptor and
CCAAT/enhancer binding protein transcription factors in cultured
human sebocytes. J Invest Dermatol 2003; 121:441-7.
Fechner H, Wang X, Srour M, Siemetzki U, Seltmann
H, Sutter AP, Scherubl H, Zouboulis CC, Schwaab R, Hillen W, Schultheiss
HP & Poller W. A novel tetracycline-controlled transactivator-transrepressor
system enables external control of oncolytic adenovirus replication.
Gene Ther 2003; 10:1680-90.
Niemann C, Unden AB, Lyle S, Zouboulis ChC, Toftgard
R & Watt FM. Indian hedgehog and beta-catenin signaling: Role
in the sebaceous lineage of normal and neoplastic mammalian epidermis.
Proc Natl Acad Sci USA 2003; 100:11873-11880.
Wróbel A, Seltmann H, Fimmel S, Muller-Decker
K, Tsukada M, Bogdanoff B, Mandt N, Blume-Peytavi U, Orfanos CE
& Zouboulis CC. Differentiation and apoptosis in human immortalized
sebocytes. J Invest Dermatol 2003; 120:175-81.
Zouboulis CC, Seltmann H, Hiroi N, Chen W, Young
M, Oeff M, Scherbaum WA, Orfanos CE, McCann SM & Bornstein
SR. Corticotropin releasing hormone: an autocrine hormone that
promotes lipogenesis in human sebocytes. Proc Natl Acad Sci USA
2002; 99:7148-53.
Fimmel S, Saborowski A, Orfanos CE & Zouboulis
CC. Development of efficient transient transfection systems for
introducing antisense oligonucleotides into human epithelial skin
cells. Horm Res 2000; 54:306-11.
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