Contact
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Coordinator
Olivier Toussaint, PhD
Contact and information
Béatrice Rayet, PhD
LINK-AGE deputy coordinator
The University of Namur
URBC - 61, rue de Bruxelles
B-5000 Namur - Belgium
Tel: * 32 (0) 81 72 41 07
Fax: * 32 (0) 81 72 41 35
beatrice.rayet@fundp.ac.be
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LINK-AGE
: coordination and consolidation of European biogerontology: en
route towards formation of a European college of biogerontology
|
News
in ageing research |
Specialized
journals
Ageing
Research Reviews
Mechanisms
of Ageing and Development
Journal
of Gerontology
Biogerontology
European
journal of ageing
International
journal of ageing and later life
The internet journal of geriatrics and gerontology
Neurobiology
of ageing
Archives of gerontology and Geriatrics
Experimental
Gerontology
Psychology
and Ageing Journal of ageing studies
March 2010
Quantitative
theory of telomere length regulation and cellular senescence. Ignacio
A. Rodriguez-Brenes1 and Charles S. Peskin. PNAS Published online
before print March 5, 2010. Link.
Arrestin
and the Multi-PDZ domain containing protein MPZ-1 interact with PTEN
and regulate C. elegans longevity. Aimee Palmitessa and Jeffrey L
Benovic. J. Biol. Chem. published 5 March 2010. Link.
Feedback between p21 and reactive oxygen production is necessary for cell senescence
Joăo
F Passos, Glyn Nelson, Chunfang Wang, Torsten Richter, Cedric
Simillion, Carole J Proctor, Satomi Miwa, Sharon Olijslagers, Jennifer
Hallinan, Anil Wipat, Gabriele Saretzki, Karl Lenhard Rudolph, Tom B L
Kirkwood & Thomas von Zglinicki. Molecular Systems Biology 6
Article number: 347. Link.
February 2010
Arboreality
has allowed for the evolution of increased longevity in mammals. Milena
R. Shattuck and Scott A. Williams. PNAS February 22. Link.
Rodríguez-Grańa L, Calliari D, Tiselius P, Hansen BW, Sköld HN
Gender-specific
ageing and non-Mendelian inheritance of oxidative damage in marine
copepods. MEPS 401:1-13. Paper on open access here.
CENP-A
reduction induces a p53-dependent cellular senescence response to
protect cells from executing defective mitoses. Kayoko Maehara, Kohta
Takahashi, and Shigeaki Saitoh. Mol. Cell. Biol. published 16 February
2010. Abstract.
Wild-type
and HUPKI ( human P53 knock-in)murine embryonic fibroblasts: P53/ARF
pathway disruption in spontaneous escape from senescence. Catherine
Whibley, Adam F. Odell, Tatiana Nedelko, Gregor Balaburski, Maureen
Murphy, Zhipei Liu, Louisa Stevens, John H. Walker, Michael Routledge,
and Monica Hollstein. J. Biol. Chem. published 4 February 2010. Link.
WIP1
phosphatase at the crossroads of cancer and aging. Xavier Le Guezennec,
Dmitry V. Bulavin. Trends in Biochemical Sciences Volume 35, Issue 2,
Pages 109-114. Link.
New vaccine tailored to the weakened elderly immune system p137. Charlotte Schubert. News. Nature Medicine 16, 137. Link.
Wild-type
and human HUPKI ( human P53 knock-in)murine embryonic fibroblasts:
P53/ARF pathway disruption in spontaneous escape from senescence.
Catherine Whibley, Adam F. Odell, Tatiana Nedelko, Gregor Balaburski,
Maureen Murphy, Zhipei Liu, Louisa Stevens, John H. Walker, Michael
Routledge, and Monica Hollstein. J. Biol. Chem. published 29
January 2010. Link.
Chromatin
repair after oxidative stress: Role of PARP-mediated proteasome
activation. Betul Catalgol, Brigitte Wendt, Stephanie Grimm, Nicolle
Breusing, Nesrin Kartal Özer, Tilman Grune. Free Radical Biology and
Medicine Volume 48, Issue 5, Pages 673-680. Link.
Update
on the oxidative stress theory of aging: Does oxidative stress play a
role in aging or healthy aging? Adam B. Salmon, Arlan Richardson,
Viviana I. Pérez. Free Radical Biology and Medicine Volume 48, Issue 5,
Pages 642-655. Link.
January 2010
Prevention
of premature senescence requires JNK regulation of Bcl-2 and reactive
oxygen species. J -J Lee, J -H Lee, Y -G Ko, S I Hong and J -S Lee.
Oncogene 2010 29: 561-575. Link.
A
G1 Checkpoint Mediated by the Retinoblastoma Protein That Is
Dispensable in Terminal Differentiation but Essential for Senescence.
Srikanth Talluri, Christian E. Isaac, Mohammad Ahmad, Shauna A. Henley,
Sarah M. Francis, Alison L. Martens, Rod Bremner, and Frederick A.
Dick. Mol. Cell. Biol. 2010;30 948-960. Link.
BNDF
modulates normal human hippocampal ageing. F Sambataro, V P Murty, H S
Lemaitre, J D Reed, S Das, T E Goldberg, J H Callicott, D R Weinberger
and V S Mattay. Mol Psychiatry 2010 15: 116-118. Link.
Senescence: A key role for CDK2. Emily J. Chenette. Nature Reviews Cancer 10, 84. Link.
The
Polarisome Is Required for Segregation and Retrograde Transport of
Protein Aggregates. B. Liu, L. Larsson, A. Caballero, X. Hao, D. Öling,
J. Grantham, and T. Nyström. Cell, Volume 140, Issue 2, 257-267. Link.
Evolution
in Health and Medicine Sackler Colloquium: Genetic variation in human
telomerase is associated with telomere length in Ashkenazi
centenarians. Gil Atzmon, Miook Cho, Richard M. Cawthon, Temuri
Budagov, Micol Katz, Xiaoman Yang, Glenn Siegel, Aviv Bergman, Derek M.
Huffman, Clyde B. Schechter, Woodring E. Wright, Jerry W. Shay, Nir
Barzilai, Diddahally R. Govindaraju, and Yousin Suh. PNAS. Link.
Regulation
of ploidy and senescence by the AMPK-related kinase NUAK1. Nicolas
Humbert, Naveenan Navaratnam, Arnaud Augert, Marco Da Costa, Sébastien
Martien, Jing Wang, Dolores Martinez, Corinne Abbadie, David Carling,
Yvan de Launoit, Jesus Gil and David Bernard. The EMBO Journal (2010),
29, 376 - 386. Link.
Signaling
through Tyr985 of Leptin Receptor as an Age/diet-dependent Switch in
the Regulation of Energy Balance. Jia You, Yue Yu, Lei Jiang, Wenxia
Li, Xinxin Yu, Lety Gonzalez, Guoqing Yang, Zunji Ke, Wenjun Li, Cai
Li, and Yong Liu. Mol. Cell. Biol. published 19 January 2010. Link.
Plasticity
of telomere maintenance mechanisms in yeast. Neal F. Lue. Trends in
Biochemical Sciences Volume 35, Issue 1, Pages 8-17. Link.
Cytokine
expression and signaling in drug-induced cellular senescence. Z
Novakova, S Hubackova, M Kosar, L Janderova-Rossmeislova, J Dobrovolna,
P Vasicova, M Vancurova, Z Horejsi, P Hozak, J Bartek and Z Hodny.
Oncogene 2010 29: 273-284. Link.
November
Genetic
variation in human telomerase is associated with telomere length in
Ashkenazi centenarians. Gil Atzmon, Miook Cho, Richard M.
Cawthon, Temuri Budagov, Micol Katz, Xiaoman Yang, Glenn
Siegel, Aviv Bergman, Derek M. Huffman, Clyde B.
Schechter, Woodring E. Wright, Jerry W. Shay, Nir
Barzilai, Diddahally R. Govindaraju and Yousin Suh. Published
online before print November 13, 2009. Link.
Increased
muscle PGC-1α expression protects from sarcopenia and metabolic disease
during aging. Tina Wenz, Susana G. Rossi, Richard L.
Rotundo, Bruce M. Spiegelman and Carlos T. Moraes. Published
online before print November 16, 2009. Link.
Age-related
hearing loss in C57BL/6J mice is mediated by Bak-dependent
mitochondrial apoptosis. Shinichi Someya, Jinze Xu, Kenji Kondo, Dalian
Ding, Richard J. Salvi, Tatsuya Yamasoba, Peter S. Rabinovitch, Richard
Weindruch, Christiaan Leeuwenburgh, Masaru Tanokura, and Tomas A.
Prolla. PNAS November 17, 2009 vol. 106 no.
46 19432-19437. Link.
Cannabinoid
agonist WIN-55,212-2 partially restores neurogenesis in the aged rat
brain. Y Marchalant, H M Brothers and G L Wenk. Mol Psychiatry 2009 14:
1068-1069. Link.
New
neuron production can be increased in the hippocampus of aged rats
following cannabinoid treatment. Y Marchalant, H M Brothers and G L
Wenk. Mol Psychiatry 2009 14: 1067. Link.
SnoN
functions as a tumour suppressor by inducing premature senescence. Deng
Pan, Qingwei Zhu and Kunxin Luo. The EMBO Journal (2009), 28, 3500 -
3513. Link.
Fibroblasts
from long-lived mutant mice show diminished ERK1/2 phosphorylation but
exaggerated induction of immediate early genes. Liou Y. Sun, Michael J.
Steinbaugh, Michal M. Masternak, Andrzej Bartke, Richard A. Miller.
Free Radical Biology and Medicine Volume 47, Issue 12, Pages 1753-1761.
Link.
Age-related
hearing loss in C57BL/6J mice is mediated by Bak-dependent
mitochondrial apoptosis. Shinichi Someya, Jinze Xu, Kenji Kondo, Dalian
Ding, Richard J. Salvi, Tatsuya Yamasoba, Peter S. Rabinovitch, Richard
Weindruch, Christiaan Leeuwenburgh, Masaru Tanokura and Tomas A.
Proll. Published online before print November 9. PNAS. Link.
Starvation
Protects Germline Stem Cells and Extends Reproductive Longevity in C.
elegans. Giana Angelo and Marc R. Van Gilst. Science 13 November 2009:
Vol. 326. no. 5955, pp. 954 - 958. Link.
Activation
of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and
cellular senescence in adult T-cell leukemia cells. H Hasegawa, Y
Yamada, H Iha, K Tsukasaki, K Nagai, S Atogami, K Sugahara, K Tsuruda,
A Ishizaki and S Kamihira. Leukemia 2009 23: 2090-2101. Link.
Angiotensin
II type 1 receptor-associated protein prevents vascular smooth muscle
cell senescence via inactivation of calcineurin/nuclear factor of
activated T cells pathway. Li-Juan Min, Masaki Mogi, Kouichi Tamura,
Jun Iwanami, Akiko Sakata, Teppei Fujita, Kana Tsukuda, Fei Jing,
Masaru Iwai and Masatsugu Horiuchi. Journal of Molecular and Cellular
Cardiology Volume 47, Issue 6, Pages 798-809. Link.
A
longevity protein, Lag2, interacts with SCF complex and regulates SCF
function. Yuan Liu, Satoru Mimura, Tsutomu Kishi and Takumi Kamura. The
EMBO Journal (2009), 28, 3366 - 3377. Link.
Ionizing
radiation induces cellular senescence of articular chondrocytes via
negative regulation of SIRT1 by p38 kinase. Eun-Hee Hong, Su-Jae Lee,
Jae-Sung Kim, Kee-Ho Lee, Hong-Duck Um, Jae-Hong Kim, Song-Ja Kim,
Jong-Il Kim, and Sang-Gu Hwang. J. Biol. Chem. published 3 November
2009. Link.
Water-
and nutrient-dependent effects of dietary restriction on Drosophila
lifespan. William W. Ja, Gil B. Carvalho, Brian M. Zid, Elizabeth M.
Mak, Ted Brummel, and Seymour Benzer. PNAS November 3,
2009 vol. 106 no. 44 18633-18637. Link.
Glucose
Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO
Activity and Aquaporin Gene Expression. S.-J. Lee, C.T. Murphy, and C.
Kenyon. Cell Metabolism, Volume 10, Issue 5, 379-391. Link.
p53-Dependent
Translational Control of Senescence and Transformation via 4E-BPs. E.
Petroulakis, A. Parsyan, R.J.O. Dowling, O. LeBacquer, Y. Martineau, M.
Bidinosti, O. Larsson, T. Alain, L. Rong, Y. Mamane, M. Paquet, L.
Furic, I. Topisirovic, D. Shahbazian, M. Livingstone, M.
Costa-Mattioli, J.G. Teodoro, and N. Sonenberg. Cancer Cell, Volume 16,
Issue 5, 439-446. Link.
Induction
of autophagy by spermidine promotes longevity. Tobias Eisenberg, Heide
Knauer, Alexandra Schauer, Sabrina Büttner, Christoph Ruckenstuhl,
Didac Carmona-Gutierrez, Julia Ring, Sabrina Schroeder, Christoph
Magnes, Lucia Antonacci, Heike Fussi, Luiza Deszcz, Regina Hartl,
Elisabeth Schraml, Alfredo Criollo, Evgenia Megalou, Daniela Weiskopf,
Peter Laun, Gino Heeren, Michael Breitenbach, Beatrix
Grubeck-Loebenstein, Eva Herker, Birthe Fahrenkrog, Kai-Uwe Fröhlich,
Frank Sinner, Nektarios Tavernarakis, Nadege Minois, Guido Kroemer
& Frank Madeo. Nature Cell Biology 11, 1305 - 1314. Link.
RelA/p65
functions to maintain cellular senescence by regulating genomic
stability and DNA repair. Jingxin Wang, Naduparambil K Jacob, Katherine
J Ladner, Amer Beg, James D Perko, Stephan M Tanner, Sandya
Liyanarachchi, Richard Fishel and Denis C Guttridge. EMBO reports
(2009), 10, 1272 - 1278. Link.
Deceptively
simple but simply deceptive – Caenorhabditis elegans lifespan studies:
Considerations for aging and antioxidant effects. Jan Gruber, Li Fang
Ng, Suresh Kumar Poovathingal, Barry Halliwell. FEBS Letters Volume
583, Issue 21, Pages 3377-3387. Link.
October
Age-associated
increase in lifespan of naďve CD4 T cells contributes to T-cell
homeostasis but facilitates development of functional
defects. Hirotake Tsukamoto, Karen Clise-Dwyer, Gail E. Huston,
Debra K. Duso, Amanda L. Buck, Lawrence L.
Johnson, Laura Haynes and Susan L. Swain. PNAS October
27, 2009 vol. 106 no. 43 18333-18338. Link.
Mechanism
of lysine oxidation in human lens crystallins during aging and in
diabetes. Xingjun Fan, Jianye Zhang, Mathilde Theves, Christopher
Strauch, Ina Nemet, Xiaoqin Liu, Juan Qian, Frank J. Giblin and Vincent
M. Monnier. JBC First Published on October 23, 2009. Link.
Water-
and nutrient-dependent effects of dietary restriction on Drosophila
lifespan. William W. Jaa, Gil B. Carvalhoa, Brian M.
Zida, Elizabeth M. Maka, Ted Brummelb and Seymour Benzer. PNAS
online October 19. Link.
DJ-1
and prevention of oxidative stress in Parkinson's disease and other
age-related disorders. Philipp J. Kahle. Jens Waak and Thomas Gasser.
Free Radical Biology and Medicine. Volume 47, Issue 10, Pages
1354-1361. Link.
JNK/FOXO-mediated
Neuronal Expression of Fly Homologue of Peroxiredoxin II Reduces
Oxidative Stress and Extends Life Span. Kyu-Sun Lee, Kanae Iijima-Ando,
Koichi Iijima, Won-Jae Lee, Joon H. Lee, Kweon Yu and Dong-Seok Lee.
The Journal of Biological Chemistry, 284, pp 29454-29461. Link.
TGF-β
enforces senescence in Myc-transformed hematopoietic tumor cells
through induction of Mad1 and repression of Myc activity. Siqin Wu,
Anne Hultquist, Per Hydbring, Cihan Cetinkaya, Fredrik Öberg,
Lars-Gunnar Larsson. Experimental Cell Research,Volume 315, Issue 18,
Pages 3099-3111. Link.
Immune
Activation in Brain Aging and Neurodegeneration: Too Much or Too
Little?. K.M. Lucin and T. Wyss-Coray. Neuron, Volume 64, Issue 1,
110-122. Link.
Stem cells: A fateful age gap. Tim Stearns. News and Views. Nature 461, 891-892. Link.
Transit-Amplifying
Cell Frequency and Cell Cycle Kinetics Are Altered in Aged Epidermis.
Alexandra Charruyer, Chantal O Barland, Lili Yue, Heike B Wessendorf,
Ying Lu, H Jeffrey Lawrence, Maria L Mancianti and Ruby Ghadially. J
Invest Dermatol 2009 129: 2574-2583. Link.
Aging
Epidermis Is Maintained by Changes in Transit-Amplifying Cell Kinetics,
Not Stem Cell Kinetics. Michael C Winter and Jackie R Bickenbach. J
Invest Dermatol 2009 129: 2541-2543. Link.
Vaccination
with Mage-b DNA induces CD8 T-cell responses at young but not old age
in mice with metastatic breast cancer. F Castro, B Leal, A Denny, R
Bahar, S Lampkin, R Reddick, S Lu and C Gravekamp.
Translational Therapeutics
BJC Open article
British Journal of Cancer (2009) 101, 1329–1337
Dispatch
Aging:
Fruit Flies Break the Chain to a Longer Life. Nancy J. Linford and
Scott D. Pletcher. Current Biology, Volume 19, Issue 19, R895-R898. Link.
Extension
of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain.
Jeffrey M. Copeland, Jaehyoung Cho, Thomas Lo, Jae H. Hur, Sepehr
Bahadorani, Tagui Arabyan, Jason Rabie, Jennifer Soh and David W.
Walker. Current Biology, Volume 19, Issue 19, 1591-1598. Link.
News of the Week
Physiology Nobel:
U.S. Researchers Recognized for Work on Telomeres
Gretchen Vogel and Elizabeth Pennisi
Science 9 October 2009: Vol. 326. no. 5950, pp. 212 - 213. Link.
Community Corner
Biomarkers for Alzheimer's disease: the dilemma of silent disease
Nature Medicine 15, 1130. Link.
Featured Review:
Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence
P.D. Adams. Molecular Cell, Volume 36, Issue 1, 2-14. Link.
Age-associated
increase in lifespan of naďve CD4 T cells contributes to T-cell
homeostasis but facilitates development of functional defects.
Hirotake Tsukamoto, Karen Clise-Dwyer, Gail E. Huston, Debra K. Duso,
Amanda L. Buck, Lawrence L. Johnson, Laura Haynes, and Susan L. Swain.
Published online before print October 8. Link.
Regenerative
Medicine Special Feature: Genetic engineering of human stem cells for
enhanced angiogenesis using biodegradable polymeric nanoparticles. Fan
Yang, Seung-Woo Cho, Sun Mi Son, Said R. Bogatyrev, Deepika Singh,
Jordan J. Green, Ying Mei, Sohyun Park, Suk Ho Bhang, Byung-Soo Kim,
Robert Langer, and Daniel G. Anderson. Published online before print
October 5, 2009. Link.
Research Highlights
Ageing: Live longer, but how? Nature 461, 700-701. Link.
News
Chromosome protection scoops Nobel
Prize for physiology or medicine awarded for uncovering role of telomeres.
Alison Abbott
Published online 5 October 2009 | 461, 706-707 (2009) Link.
Prohibitin
couples diapause signalling to mitochondrial metabolism during ageing
in C. elegans. Marta Artal-Sanz & Nektarios Tavernarakis. Nature
461, 793-797. Link.
Cell
surface-bound IL-1{alpha} is an upstream regulator of the
senescence-associated IL-6/IL-8 cytokine network. Arturo V. Orjalo,
Dipa Bhaumik, Bridget K. Gengler, Gary K. Scott, and Judith Campisi.
PNAS October 6, 2009 vol. 106 no. 40
17031-17036. Link.
LKB1
Regulates Pancreatic β Cell Size, Polarity, and Function. Z. Granot, A.
Swisa, J. Magenheim, M. Stolovich-Rain, W. Fujimoto, E. Manduchi, T.
Miki, J.K. Lennerz, C.J. Stoeckert, Jr., O. Meyuhas, S. Seino, M.A.
Permutt, H. Piwnica-Worms, N. Bardeesy, and Y. Dor. Cell Metabolism,
Volume 10, Issue 4, 296-308. Link.
Loss
of Lkb1 in Adult βCells Increases β Cell Mass and Enhances Glucose
Tolerance in Mice. A. Fu, A.C.-H. Ng, C. Depatie, N. Wijesekara, Y. He,
G.-S. Wang, N. Bardeesy, F.W. Scott, R.M. Touyz, M.B. Wheeler, and R.A.
Screaton. Cell Metabolism, Volume 10, Issue 4, 285-295. Link.
Translate This . . . during Dietary Restriction. B.K. Kennedy and V.L. MacKay. Cell Metabolism, Volume 10, Issue 4, 247-248. Link.
Reactive
Oxygen Species Enhance Insulin Sensitivity. K. Loh, H. Deng, A.
Fukushima, X. Cai, B. Boivin, S. Galic, C. Bruce, B.J. Shields, B.
Skiba, L.M. Ooms, N. Stepto, B. Wu, C.A. Mitchell, N.K. Tonks, M.J.
Watt, M.A. Febbraio, P.J. Crack, S. Andrikopoulos, and T. Tiganis. Cell
Metabolism, Volume 10, Issue 4, 260-272. Link.
Telomeric circles: universal players in telomere maintenance? pp1010 - 1015
Lubomir
Tomaska, Jozef Nosek, Juraj Kramara and Jack D Griffith. Nature
Structural & Molecular Biology 16, 1010 - 1015. Link.
Rb2/p130
is the dominating pocket protein in the p53–p21 DNA damage response
pathway leading to senescence. H Helmbold, N Kömm, W Deppert and W
Bohn. Oncogene 2009 28: 3456-3467. Link.
Effect
of a nutrient-enriched drink on dietary intake and nutritional status
in institutionalised elderly. M Manders, C P G M de Groot, Y H Blauw, R
A M Dhonukshe-Rutten, L van Hoeckel-Prüst, J G Bindels, E Siebelink and
W A van Staveren. Eur J Clin Nutr 2009 63: 1241-1250. Link.
Cell
surface-bound IL-1{alpha} is an upstream regulator of the
senescence-associated IL-6/IL-8 cytokine network. Arturo V. Orjalo,
Dipa Bhaumik, Bridget K. Gengler, Gary K. Scott, and Judith Campisi. Link.
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
C. Selman et al. Science 2 October 2009: Vol. 326. no. 5949, pp. 140 - 144. Abstract.
4E-BP
Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial
Activity in Drosophila. B.M. Zid, A.N. Rogers, S.D. Katewa, M.A.
Vargas, M.C. Kolipinski, T.A. Lu, S. Benzer, and P. Kapahi. Cell,
Volume 139, Issue 1, 149-160. Link.
September
A
quantitative model for age-dependent expression of the p16INK4a tumor
suppressor. Denis Tsygankov, Yan Liu, Hanna K. Sanoff, Norman E.
Sharpless, and Timothy C. Elston. PNAS vol. 106 no. 39,
pp16562-16567. Link.
The
regulation of aging: does autophagy underlie longevity? Tibor Vellai,
Krisztina Takács-Vellai, Miklós Sass and Daniel J. Klionsky. Trends in
Cell Biology, Volume 19, Issue 10, Pages 487-494. Link.
RAS
in cellular transformation and senescence. Gina M. DeNicola, David A.
Tuveson. European Journal of Cancer, Volume 45, Supplement 1, Pages
211-216. Link.
A
quantitative model for age-dependent expression of the p16INK4a tumor
suppressor. Denis Tsygankova, Yan Liub, Hanna K. Sanoffb, Norman
E. Sharpless and Timothy C. Elston. Published online before print
September 14, 2009. Link.
From
the Rarest to the Most Common: Insights from Progeroid Syndromes into
Skin Cancer and Aging. Brian C Capell, Brook E Tlougan and Seth J
Orlow. J Invest Dermatol 2009 129: 2340-2350. Link.
PD-1+
memory phenotype CD4+ T cells expressing C/EBP{alpha} underlie T cell
immunodepression in senescence and leukemia. Kenichiro Shimatani,
Yasuhiro Nakashima, Masakazu Hattori, Yoko Hamazaki, and Nagahiro
Minato. PNAS September 15, 2009 vol. 106 no. 37 15807-15812 Link.
SIRT1
markedly extends replicative lifespan if the NAD+ salvage pathway is
enhanced. Cynthia Ho, Eric van der Veer, Oula Akawi, J. Geoffrey
Pickering. FEBS Letters
Volume 583, Issue 18, Pages 3081-3085. Link.
PARP-1
Deficiency Increases the Severity of Disease in a Mouse Model of
Multiple Sclerosis. Vimal Selvaraj, Mangala M. Soundarapandian, Olga
Chechneva, Ambrose J. Williams, Maxim K. Sidorov, Athena M. Soulika,
David E. Pleasure, and Wenbin Deng. J. Biol. Chem. 2009;284
26070-26084. Link.
Drastic
increase of myosin light chain MLC-2 in senescent skeletal muscle
indicates fast-to-slow fibre transition in sarcopenia of old age. Joan
Gannon, Philip Doran, Anne Kirwan, Kay Ohlendieck. European Journal of
Cell Biology, Volume 88, Issue 11Pages 685-700. Link.
Ageing: Secrets of a long life. Charlotte Harrison. Nature Reviews Drug Discovery 8, 698-699. Link.
Connecting obesity, aging and diabetes. Rexford S. Ahima. News and Views, Nature Medicine 15, pp996 - 997. Link.
Senescence
and p130/Rbl2: a new beginning to the end. Francesco P Fiorentino,
Catherine E Symonds, Marcella Macaluso and Antonio Giordano. Cell Res
2009 19: 1044-1051. Link.
Papillary
hyperplasia of the gallbladder in pancreaticobiliary maljunction
represents a senescence-related lesion induced by lysolecithin. Junpei
Yamaguchi, Motoko Sasaki, Kenichi Harada, Yoh Zen, Yasunori Sato,
Hiroko Ikeda, Keita Itatsu, Yukihiro Yokoyama, Hisami Ando, Tetsuo
Ohta, Akio Kubota, Koichi Shimizu, Yuji Nimura, Masato Nagino and
Yasuni Nakanuma. Laboratory Investigation (2009) 89, 1018–1031. Link.
JNK/FOXO-mediated
neuronal expression of fly homologue of peroxiredoxin II reduces
oxidative stress and extends lifespan. Kyu-Sun Lee, Kanae Iijima-Ando,
Koichi Iijima, Won-Jae Lee, Joon H. Lee, Kweon Yu, and Dong-Seok Lee.
J. Biol. Chem. published 31 August 2009. Link.
Collapse
of proteostasis represents an early molecular event in Caenorhabditis
elegans aging. Anat Ben-Zvi, Elizabeth A. Miller, and Richard I.
Morimoto. PNAS vol. 106 no. 35 14914-14919. Abstract.
p53
isoforms Δ133p53 and p53β are endogenous regulators of replicative
cellular senescence. Kaori Fujita, Abdul M. Mondal, Izumi Horikawa,
Giang H. Nguyen, Kensuke Kumamoto, Jane J. Sohn, Elise D. Bowman, Ewy
A. Mathe, Aaron J. Schetter, Sharon R. Pine, Helen Ji, Borivoj
Vojtesek, Jean-Christophe Bourdon, David P. Lane and Curtis C. Harris.
Nature Cell Biology 11, pp1135 - 1142. Link.
Ageing: Secrets of a long life. Charlotte Harrison. Nature Reviews Drug Discovery 8, 698-699. Link.
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